Proximal tubule - targeted heme oxygenase - 1 in cisplatin - induced acute kidney injury 1 2 3 4
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چکیده
Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury 1 2 3 4 Subhashini Bolisetty, Amie Traylor, Reny Joseph, Abolfazl Zarjou, Anupam 5 Agarwal 6 7 Department of Medicine, Nephrology Research and Training Center and Department of Cell, 8 Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, 9 Alabama 35294, Birmingham Veterans Administration Medical Center, Birmingham, 10 Birmingham 35294, USA 11 12
منابع مشابه
Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury.
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that catalyzes the breakdown of heme to biliverdin, carbon monoxide, and iron. The beneficial effects of HO-1 expression are not merely due to degradation of the pro-oxidant heme but are also credited to the by-products that have potent, protective effects, including antioxidant, anti-inflammatory, and prosurvival properties. This is well refle...
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Heme oxygenase-1 (HO-1) is a 32-kDa microsomal enzyme that catalyzes the conversion of heme to biliverdin, releasing iron and carbon monoxide. Induction of HO-1 occurs as a protective response in cells/tissues exposed to a wide variety of oxidant stimuli. The chemotherapeutic effects of cis-diamminedichloroplatinum(II) (cisplatin), a commonly used anticancer drug, are limited by significant nep...
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Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: heavy chain and light chain. The ferritin heavy chain (FtH) has ferroxidase activity that is required for iron incorporation and limiting toxicity. The purpose of this study was to investigate the role of FtH in acute kidney injury (AKI) and renal iron handling by using proximal tubule-specific FtH-knockout ...
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Hepatic ischemic-reperfusion injury (HIRI) is considered a risk factor for clinical acute kidney injury (AKI). However, HIRI's impact on renal tubular cell homeostasis and subsequent injury responses remain ill-defined. To explore this issue, 30-45 min of partial HIRI was induced in CD-1 mice. Sham-operated or normal mice served as controls. Renal changes and superimposed injury responses (glyc...
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تاریخ انتشار 2015